Distinct Molecular Structures and Hydrogen Bond Patterns of a, a-diethyl-substituted Cyclic Imide, Lactam, and Acetamide-derivatives in the Crystalline Phase

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dc.contributor.authorKrivoshein, Arcadius
dc.date.accessioned2020-05-26T15:56:47Z
dc.date.available2020-05-26T15:56:47Z
dc.date.issued2016
dc.description.abstractα,α-Dialkyl- and α-alkyl-α-aryl-substituted cyclic imides, lactams, and acetamides show promising anticonvulsant, anxiolytic, and anesthetic activities. While a number of crystal structures of various α-substituted cyclic imides, lactams, and acetamides were reported, no in-depth comparison of crystal structures and solid-state properties of structurally matched compounds have been carried out so far. In this paper, we report molecular structure and intermolecular interactions of three α,α-diethyl-substituted compounds – 3,3-diethylpyrrolidine-2,5-dione, 3,3-diethylpyrrolidin-2-one, and 2,2-diethylacetamide – in the crystalline phase, as studied using single-crystal X-ray diffraction and IR spectroscopy. We found considerable differences in the patterns of H-bonding and packing of the molecules in crystals. These differences correlate with the compounds’ melting points and are of significance to physical pharmacy and formulation development of neuroactive drugs.en_US
dc.identifier.citation3. Krivoshein, A. V., Ordonez, C., Khrustalev, V. N., and Timofeeva, T. V. (2016) Distinct molecular structures and hydrogen bond patterns of a,a-diethyl-substituted cyclic imide, lactam, and acetamide derivatives in the crystalline phase, Journal of Molecular Structure, 1121, 196-202.en_US
dc.identifier.urihttps://hdl.handle.net/10657.1/2347
dc.publisherJournal of Molecular Structureen_US
dc.subjectCyclic imides Lactams Acetamides Antiepileptic X-Ray diffraction IR spectroscopyen_US
dc.titleDistinct Molecular Structures and Hydrogen Bond Patterns of a, a-diethyl-substituted Cyclic Imide, Lactam, and Acetamide-derivatives in the Crystalline Phaseen_US
dc.typeArticleen_US

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Arcadius V. Krivoshein