Institutional Repository @ UHCL
Institutional Repository @ UHCL is a digital service provided by Neumann Library that preserves and provides access to the scholarship and creative works produced and owned by the University of Houston-Clear Lake community.
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Restoring Membrane Protein Trafficking Rescues the Effects of Aneuploidy on Cellular Aging
(2016)Aneuploidy and aging are correlated; however, a causal link between these two phenomena has remained elusive. Here, we show that yeast disomic for a single native yeast chromosome generally have a decreased replicative ... -
New Functional and Biophysical Insights into the Mitochondrial Rieske Iron-Sulfur Protein from Genetic Suppressor Analysis
(WORM, 2016)Several intragenic mutations suppress the C. elegans isp-1 (qm150) allele of the mitochondrial Rieske iron-sulfur protein (ISP), a catalytic subunit of Complex III of the respiratory chain. These mutations were located ... -
CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes
(PNAS, 2018)Transcriptional regulation plays an important role in the control of gene expression during aging. However, translation efficiency likely plays an equally important role in determining protein abundance, but has been ... -
CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes
(Cell Rep, 2017)Transcriptional regulation plays an important role in the control of gene expression during aging. However, translation efficiency likely plays an equally important role in determining protein abundance, but has been ... -
Transaldolase Inhibition Impairs Mitochondrial Respiration and Induces a Starvation-like Longevity Response in Caenorhabditis Elegans
(PMID, 2017)Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanism exists to cope with disruptions to mitochondrial function that promote cellular health and ...
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