Changes in NMDA Receptor Expression in Auditory Cortex after Learning

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dc.citation.issueNumberSun, W., E. Mercado III, P. Wang, X. Shan, T. C. Lee, and R. J. Salvi. “Changes in NMDA Receptor Expression in Auditory Cortex after Learning”, Neuroscience Letter, 374(1): 63-68, 2005.
dc.contributor.authorSun, W.
dc.contributor.authorMercado III, E.
dc.contributor.authorWang, P.
dc.contributor.authorShan, Xiaojun
dc.contributor.authorLee, T. C.
dc.contributor.authorSalvi, R. J.
dc.date.accessioned2019-10-31T15:17:51Z
dc.date.available2019-10-31T15:17:51Z
dc.date.issued2005
dc.description.abstractExtensive practice on auditory learning tasks dramatically alters the functional organization and response properties of neurons in the auditory cortex. The cellular mechanisms responsible for this auditory learning-induced cortical plasticity are unclear; however, changes in synaptic function involving NMDA receptors have been strongly implicated. To test this hypothesis, we measured the change in gene expression of NMDA receptors and associated proteins in the auditory cortex of adult rats trained to perform an auditory identification task. NMDA receptor 2A and 2B gene expression in auditory cortex decreased significantly as auditory discrimination improved whereas expression of Arc, an immediate early gene involved in memory stabilization, increased. These results suggest that changes in NMDA receptors 2A and 2B and Arc enhance synaptic plasticity, thereby facilitating experience-dependent cortical remodeling and auditory learning.en_US
dc.identifier.urihttps://hdl.handle.net/10657.1/1628
dc.relation.ispartofseriesNeuroscience Letter;Vol. 374, pp. 63-68
dc.titleChanges in NMDA Receptor Expression in Auditory Cortex after Learningen_US
dc.typeArticleen_US

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College of Science and Engineering
Xiaojun "Gene" Shan