Yeast Replicative Aging; A Paradigm for Defining Conserved Longevity Interventions

dc.contributor.author	Wasko, Brian
dc.date.accessioned	2021-03-08T17:34:33Z
dc.date.available	2021-03-08T17:34:33Z
dc.date.issued	2014
dc.description.abstract	The finite replicative life span of budding yeast mother cells was demonstrated as early as 1959, but the idea that budding yeast could be used to model aging of multicellular eukaryotes did not enter the scientific mainstream until relatively recently. Despite continued skepticism by some, there are now abundant data that several institutions capable of extending yeast replicative life span have similar effect in multicellular eukaryotes including nematode worms, fruit flies, and rodents. In particular, dietary restriction, mTOR signaling, and sirtuins are among the most studied longevity interventions in the field. Here, we describe key conserved longevity pathways in yeast and discuss relationships that may help explain how such broad conservation of aging process could have evolved.	en_US
dc.identifier.citation	Wasko, BM and Kaeberlein M. Yeast replicative aging: A paradigm for defining conserved longevity interventions. FEMS Yeast Res. 2014 Feb;14(1):148-59. PMID: 24119093.	en_US
dc.identifier.uri	https://hdl.handle.net/10657.1/2557
dc.publisher	FEMS Yeast Research	en_US
dc.subject	Caenorhabditis elegans; caloric restriction; calorie restriction; replicative life span; target of rapamycin; yeast.	en_US
dc.title	Yeast Replicative Aging; A Paradigm for Defining Conserved Longevity Interventions	en_US
dc.type	Article	en_US

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