Arcadius V. Krivoshein
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Dr. Arcadius V. Krivoshein is an Assistant Professor of Chemistry, at University of Houston-Clear Lake. Dr. Krivoshein's research interests are in the areas of Analytical chemistry, (U)HPLC and mass spectrometry method development;Biochemistry and biophysics of proteins and peptides;Solid-state chemistry and molecular pharmaceutics of antiepileptic drugs; Medicinal chemistry and molecular pharmacology, especially as applied to receptors and ion channels.
Recent Submissions
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Absolute Configuration and Polymorphism of 2-phenylbutyramide and a-methyl -a-phenylsuccinimide
(Crystal Growth & Designs, 2014)Crystal structures of racemic and homochiral forms of 2-phenylbutyramide (1) and 3-methyl-3-phenylpyrrolidine-2,5-dione (2) were investigated in detail by a single crystal X-ray diffraction study. Absolute configurations ... -
Anticonvulsants Based on the a-substituted Amide Group Pharmacophore Bind to and Inhibit Functions of Neuronal Nicotinic Acetylcholine Receptors
(ACS Chemical Neuroscience, 2016)Although the antiepileptic properties of α-substituted lactams, acetamides, and cyclic imides have been known for over 60 years, the mechanism by which they act remains unclear. I report here that these compounds bind to ... -
Distinct Molecular Structures and Hydrogen Bond Patterns of a, a-diethyl-substituted Cyclic Imide, Lactam, and Acetamide-derivatives in the Crystalline Phase
(Journal of Molecular Structure, 2016)α,α-Dialkyl- and α-alkyl-α-aryl-substituted cyclic imides, lactams, and acetamides show promising anticonvulsant, anxiolytic, and anesthetic activities. While a number of crystal structures of various α-substituted cyclic ... -
Anticonvulsant Lactams, Cyclic Imides and Acetamides: From Chemical Crystallograpy to Molecular Pharmaceutics
(Current Pharmaceutical Designs, 2016)The antiepileptic activity of α-substituted acetamides, lactams, and cyclic imides has been known for over six decades. We recently proposed an α-substituted amide group as the minimum pharmacophore responsible for inhibition ... -
Molecular Pharmaceutics and Solid-state Chemistry of Drugs
(Current Pharmaceutical Design, 2016) -
Racemic and Enantiopure forms of 3-ethyl-3-phenylpyrrolidin-2-one Adopt Very Different Crystal Structures
(Chirality, 2017)3-Ethyl-3-phenylpyrrolidin-2-one (EPP) is an experimental anticonvulsant based on the newly proposed α-substituted amide group pharmacophore. These compounds show robust activity in animal models of drug-resistant epilepsy ...
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