Institutional Repository @ UHCL: Recent submissions
Now showing items 1-20 of 2036
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PMT1 Deficiency Enhances Basal UPR Activity and Extends Replicative Lifespan of Sacchraromyces cerevisiae
(Age (Dordr), 2015)Pmt1p is an important member of the protein O-mannosyltransferase (PMT) family of enzymes, which participates in the endoplasmic reticulum (ER) unfolded protein response (UPR), an important pathway for alleviating ER stress. ... -
THE RELATIONSHIP OF PARENTAL INVOLVEMENT AND LATINO STUDENTS ACADEMIC ACHIEVEMENT, ABSENTEEISM, AND BEHAVIOR
(2020-05-28)The purpose of this study was to examine the relationship between Hispanic parental involvement and Hispanic students’ academic achievement, absenteeism, and behavior. Fifth grade parents from four elementary schools in a ... -
CURRENT PERCEPTIONS OF SCIENCE AS A CAREER CHOICE OF UNDERREPRESENTED 11TH AND 12TH GRADE STUDENTS IN A LOW SOCIOECONOMIC AREA HIGH SCHOOL
(2020-05-13)The United States has a shortage of qualified workers in the science, technology, engineering, and mathematics (STEM) fields (Zhang & Barnett, 2015). There is a critical shortage of underrepresented students seeking science ... -
THE RELATIONSHIP BETWEEN THE USE OF METACOGNITIVE READING STRATEGIES AND STUDENT RETENTION IN HIGHER EDUCATION
(2020-05-13)Student retention is a major issue that has spanned multiple decades in higher education in the United States, corresponding with greater access to higher education and a rise in non-traditional students. Innumerable ... -
The Influence of Extrinsic Motivational Factors on Upper Elementary Students in Reading
(2020-04-17)The purpose of this study was to examine the influence of extrinsic motivational factors on upper elementary students who are reading at least two grade levels below their current grade. Research was conducted using a mixed ... -
CORRELATION OF CLAIM, EVIDENCE, AND REASONING AS A WRITING FRAMEWORK AND STUDENTS’ SUCCESS RATES IN HIGH SCHOOL SCIENCE DISTRICT STANDARDIZED TESTS
(2020-04-15)The purpose of this mixed-methods study was to examine the relationship between science writing and student science achievement and how teachers implement the writing strategy claim, evidence, and reasoning (CER) in their ... -
High School Administrator Gender and the Impact on School Factors
(2020-04-13)Female representation in leadership position around the country is on the rise. More and more females hold CEO positions, political leadership, and partnerships in law firms, fields typically dominated by males. It would ... -
Teacher Awareness of STEM Education: Industry, Resources and Student Preparation for Success in College and Career
(2020-02-25)This study examined science teachers’ perceptions and determined their level of STEM awareness and support. Survey, interview, and demographic data were collected from a purposeful sample of 124 high school science teachers ... -
H3K36 Methylation Promotes Longevity by Enhancing Transcriptional Fidelity
(Genes & Development, 2015)Epigenetic mechanisms, including histone post-translational modifications, control longevity in diverse organisms. Relatedly, loss of proper transcriptional regulation on a global scale is an emerging phenomenon of shortened ... -
Defining Molecular Basis for the Longevity Traits in Natural Yeast Isolates
(NPJ Aging Mechanisms of Disease, 2015)Background: The budding yeast has served as a useful model organism in aging studies, leading to the identification of genetic determinants of longevity, many of which are conserved in higher eukaryotes. However, factors ... -
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging
(Cell Metab, 2015)Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a ... -
Tether Mutations that Restore Function and Suppress Pleiotropic Phenotypes of the C. elegans isp-1(qm150) Rieske Iron-sulfur Protein
(PNAS, 2015)Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood disorders such as Leigh Syndrome, whereas mild disruption can extend ... -
Restoring Membrane Protein Trafficking Rescues the Effects of Aneuploidy on Cellular Aging
(2016)Aneuploidy and aging are correlated; however, a causal link between these two phenomena has remained elusive. Here, we show that yeast disomic for a single native yeast chromosome generally have a decreased replicative ... -
New Functional and Biophysical Insights into the Mitochondrial Rieske Iron-Sulfur Protein from Genetic Suppressor Analysis
(WORM, 2016)Several intragenic mutations suppress the C. elegans isp-1 (qm150) allele of the mitochondrial Rieske iron-sulfur protein (ISP), a catalytic subunit of Complex III of the respiratory chain. These mutations were located ... -
CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes
(PNAS, 2018)Transcriptional regulation plays an important role in the control of gene expression during aging. However, translation efficiency likely plays an equally important role in determining protein abundance, but has been ... -
CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes
(Cell Rep, 2017)Transcriptional regulation plays an important role in the control of gene expression during aging. However, translation efficiency likely plays an equally important role in determining protein abundance, but has been ... -
Transaldolase Inhibition Impairs Mitochondrial Respiration and Induces a Starvation-like Longevity Response in Caenorhabditis Elegans
(PMID, 2017)Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanism exists to cope with disruptions to mitochondrial function that promote cellular health and ... -
Defining the Impact of Mutation Accumulation on Replicative Lifespan in Yeast Using Cancer-associated Mutator Phenotypes
(PNAS, 2019)Mutations accumulate within somatic cells and have been proposed to contribute to aging. It is unclear what level of mutation burden may be required to consistently reduce cellular lifespan. Humans cancers driven by a ... -
Loss of Vacuolar Acidity Results in Iron Sulfur Cluster Defects and Divergent Homeostatic Responses During Aging in Saccharomyces Cerevisiae
(GeroScience, 2020)The loss of vacuolar/lysosomal acidity is an early event during aging that has been linked to mitochondrial dysfunction. However, it is unclear how loss of vacuolar acidity results in age-related dysfunction. Through ... -
Adaptive Privacy-Preserving Authentication in Vehicular Networks
(Journal of Computer Science and Technology, 2008)Vehicular networks have attracted extensive attention in recent years for their promises in improving safety and enabling other value-added services. Most previous work focuses on designing the media access and physical ...
