Now showing items 391-394 of 394
End-of-lfe Cell Cycle Arrest Contributes to Stochasticity of Yeast Replicative Aging
(FEMS Yeast Research, 2013)
There is growing evidence that stochastic events play an important role in determining individual longevity. Studies in model organisms have demonstrated that genetically identical populations maintained under apparently ...
pH Neutralization Protects Against Reduction in Replicative Lifespan Following Chronological Aging in Yeast
(Cell Cycle, 2012)
Chronological and replicative aging have been studied in yeast as alternative paradigms for post-mitotic and mitotic aging, respectively. It has been known for more than a decade that cells of the S288C background aged ...
Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae
(Experimental Gerontology, 2012)
Chronological aging of budding yeast cells result in a reduction in a subsequent replicative life span through unknown mechanisms. Here, we show that dietary restrictions during chronological aging delays the reduction ...
Yeast Replicative Aging; A Paradigm for Defining Conserved Longevity Interventions
(FEMS Yeast Research, 2014)
The finite replicative life span of budding yeast mother cells was demonstrated as early as 1959, but the idea that budding yeast could be used to model aging of multicellular eukaryotes did not enter the scientific ...