Now showing items 1-4 of 4
Suppressed Expression of Non-DSB Repair Genes Inhibits Gamma-radiation Induced Cytogenetic Repair And Cell Cycle Arrest
(DNA Repair (Amst), 2008)
Changes of gene expression profile are one of the most important biological responses in living cells after ionizing radiation (IR) exposure. Although some studies have shown that genes up-regulated by IR may play important ...
Protein expression profile changes in human fibroblasts induced by low dose energetic protons
(Advances in Space Research:Life Sciences in Space, 2009)
Extrapolation of known radiation risks to the risks from low dose and low dose-rate exposures of human population, especially prolonged exposures of astronauts in the space radiation environment, relies in part on the ...
Proapoptotic p53-Interacting Protein 53BP2 Is Induced by UV Irradiation but Suppressed by p53
(Molecular and Cellular Biology, 2000)
p53 is an important mediator of the cellular stress response with roles in cell cycle control, DNA repair, and apoptosis. 53BP2, a p53-interacting protein, enhances p53 transactivation, impedes cell cycle progression, and ...
p53-Interacting Protein 53BP2 Inhibits Clonogenic Survival and Sensitizes Cells to Doxorubicin but not Paclitaxel-induced Apoptosis
53BP2 was initially identified as a protein interacting with p53 in a yeast two-hybrid screen and subsequently shown to enhance p53 transcriptional transactivation and induce apoptosis when transiently overexpressed in ...