Now showing items 1-5 of 5
Tether Mutations that Restore Function and Suppress Pleiotropic Phenotypes of the C. elegans isp-1(qm150) Rieske Iron-sulfur Protein
Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood disorders such as Leigh Syndrome, whereas mild disruption can extend ...
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging
(Cell Metab, 2015)
Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a ...
H3K36 Methylation Promotes Longevity by Enhancing Transcriptional Fidelity
(Genes & Development, 2015)
Epigenetic mechanisms, including histone post-translational modifications, control longevity in diverse organisms. Relatedly, loss of proper transcriptional regulation on a global scale is an emerging phenomenon of shortened ...
Defining Molecular Basis for the Longevity Traits in Natural Yeast Isolates
(NPJ Aging Mechanisms of Disease, 2015)
Background: The budding yeast has served as a useful model organism in aging studies, leading to the identification of genetic determinants of longevity, many of which are conserved in higher eukaryotes. However, factors ...
PMT1 Deficiency Enhances Basal UPR Activity and Extends Replicative Lifespan of Sacchraromyces cerevisiae
(Age (Dordr), 2015)
Pmt1p is an important member of the protein O-mannosyltransferase (PMT) family of enzymes, which participates in the endoplasmic reticulum (ER) unfolded protein response (UPR), an important pathway for alleviating ER stress. ...