Now showing items 1-4 of 4
Buffering the pH of the Culture Medium does not Extend Yeast Replicative Lifespan
(F1000 Research, 2013)
During chronological aging of the budding yeast cells, the culture medium can become acidified and this acidification limits cell survival. As a consequence, buffering the culture medium to pH 6 significantly extends ...
mTOR Inhibition by Rapamycin Alleviates Mitochondrial Disease in the Ndufs4-Mouse Model of Leigh Syndrome
Mitochondrial dysfunction contributes to numerous health problems, including neurological and muscular degeneration, cardiomyopathies, cancer, diabetes, and pathologies of aging. Severe mitochondrial defects can result ...
Molecular Mechanisms Underlying Genotype-dependent Responses to Dietary Restrictions
(Aging Cell, 2013)
Dietary restriction (DR) increases lifespan and attenuates age-related phenotypes in many organisms; however, the effects of DR on longevity of individuals in genetically heterogeneous populations is not well characterized. ...
End-of-lfe Cell Cycle Arrest Contributes to Stochasticity of Yeast Replicative Aging
(FEMS Yeast Research, 2013)
There is growing evidence that stochastic events play an important role in determining individual longevity. Studies in model organisms have demonstrated that genetically identical populations maintained under apparently ...