Colleges: Recent submissions
Now showing items 1-20 of 699
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Development and Evaluation of a Decision-Making Tool for Evaluating and Selecting Prompting Strategies
(2020-05-27)An extensive literature has demonstrated the successful application of various response prompts and prompt-fading strategies for teaching students with developmental and intellectual disabilities. However, few practical ... -
Using Behavioral Skills Training to Train Police Officers to Respond to Individuals with Autism
(2020-05-27)Research indicates that individuals with autism may be more likely to encounter law enforcement due to the various unusual behaviors associated with autism (e.g., stereotypy) (Osborn, 2008). Although individuals with autism ... -
Role of Negative Personality on Sleep Quality and Emotion Regulation
(2021-05-10)The relationship between sleep and emotion regulation has been well-established. Worsened sleep quality is associated with a diminished ability to regulate emotions. However, research has yet to examine potential mediators. ... -
Drone Based Object Tracking with Camshift Algorithm and Neural Network
(2021-04-30)Integration of tracking system and the drone has been a novel research topic in recent years, especially when drones are required to implement complex tasks which cannot be done easily with human control. Usually, the drone ... -
Applying a Distributed Elasticsearch Cluster to Increased Security in IOT Devices
(2021-04-28)Internet of Things devices have permeated the daily lives of many by offering useful insights into their daily lives through the use of sensors and cameras to collect and display real-world data. Increasingly, these devices ... -
A Sliding Window Based Voting Classifier for Activity Sensor Based User Identification
(2021-04-30)Identification is the core of any authentication protocol design as the purpose of the authentication is to verify the user’s identity. The efficient establishment and verification of identity remain a big challenge. ... -
Build a Game-Theoretic Framework for Community’s Role in Counter-Terrorism
(2021-03-24)Terrorism poses a major challenge to the government whenever it surfaces in any nation. It degrades the economic, infrastructural and trading systems. Furthermore, it reduces international revenues from tourism and foreign ... -
Reflections of Fear: Mass Hysteria in Cold War Cinema 1946-1991
(2021-05-12)The Cold War was one of the longest and most complicated wars in American History. It lasted from 1946-1991 and was entrenched in every person’s life in the United States. It was a time of great fear and suspicion. Americans ... -
Pivaloyloxtmethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation
(Biorg Med Chem, 2008)Nitrogenous bisphosphonate inhibitors of farnesyl disphosphate synthase have been used clinically for treatment of bone disease. Because many of their effects may be mediated by depletion of geranylgeranyl diphosphate, ... -
Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae
(DNA Repair, 2009)Yeast rad50 and mre11 nuclease mutants are hypersensitive to physical and chemical agents that induce DNA double-strand breaks (DSBs). This sensitivity was suppressed by elevating intracellular levels of TLC1, the RNA ... -
Synthesis and Biological Evaluation of a Series of Aromatic Bisphospohonates
(Bioorg Med Chem, 2010)Geminal bisphosphonates display varied biological activity depending on the nature of the substituents on the central carbon atom. For example, the nitrogenous bisphosphonates zoledronate and risedronate inhibit the enzyme ... -
Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate
(J Pharmacol Exp Ther., 2011)Multiple studies have implicated the depletion of isoprenoid biosynthetic pathway intermediates in the induction of autophagy. However, the exact mechanism by which isoprenoid biosynthesis inhibitors induce autophagy has ... -
A Novel Squalene Synthase inhibitor Combined with a Statin or Nitrogenous Biphosphonate in vitro
(J. Lipid Res., 2011)Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and ... -
pH Neutralization Protects Against Reduction in Replicative Lifespan Following Chronological Aging in Yeast
(Cell Cycle, 2012)Chronological and replicative aging have been studied in yeast as alternative paradigms for post-mitotic and mitotic aging, respectively. It has been known for more than a decade that cells of the S288C background aged ... -
Quantitative determination of isopentenyl diphosphate in cultured mammalian cells
(Analytical Biochemistry, 2012)Isopentenyl diphosphate (IPP), an intermediate of the isoprenoid biosynthetic pathway (IBP), has several important biological functions, yet a method to determine its basal level has not been described. Here, we describe ... -
Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae
(Experimental Gerontology, 2012)Chronological aging of budding yeast cells result in a reduction in a subsequent replicative life span through unknown mechanisms. Here, we show that dietary restrictions during chronological aging delays the reduction ... -
Yeast Replicative Aging; A Paradigm for Defining Conserved Longevity Interventions
(FEMS Yeast Research, 2014)The finite replicative life span of budding yeast mother cells was demonstrated as early as 1959, but the idea that budding yeast could be used to model aging of multicellular eukaryotes did not enter the scientific ... -
mTOR Inhibition by Rapamycin Alleviates Mitochondrial Disease in the Ndufs4-Mouse Model of Leigh Syndrome
(Science, 2013)Mitochondrial dysfunction contributes to numerous health problems, including neurological and muscular degeneration, cardiomyopathies, cancer, diabetes, and pathologies of aging. Severe mitochondrial defects can result ... -
End-of-lfe Cell Cycle Arrest Contributes to Stochasticity of Yeast Replicative Aging
(FEMS Yeast Research, 2013)There is growing evidence that stochastic events play an important role in determining individual longevity. Studies in model organisms have demonstrated that genetically identical populations maintained under apparently ... -
Molecular Mechanisms Underlying Genotype-dependent Responses to Dietary Restrictions
(Aging Cell, 2013)Dietary restriction (DR) increases lifespan and attenuates age-related phenotypes in many organisms; however, the effects of DR on longevity of individuals in genetically heterogeneous populations is not well characterized. ...
