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dc.contributor.authorWasko, Brian
dc.date.accessioned2021-02-02T17:18:28Z
dc.date.available2021-02-02T17:18:28Z
dc.date.issued2014
dc.identifier.citation13. Zhao W, Fang BX, Niu YJ, Liu YN, Liu B, Peng Q, Li JB, Wasko BM, Delaney JR, Kennedy BK, Suh Y, Zhou ZJ, Kaeberlein M, Liu XG. Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. Mech Ageing Dev. 2014.en_US
dc.identifier.urihttps://hdl.handle.net/10657.1/2553
dc.description.abstractSaccaromyces cerevisiae Nar lp is an essential Fe/S protein that exhibits striking similarity to bacterial iron-only hydogenases. Nar1p is required for the maturation of cytosolic and nuclear, but not of mitochondrial Fe/S proteins, and plays a role in modulating sensitivity to oxygen in both yeast and Caenorhabditis elegans through unknown mechanisms. Here we report that Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. These data suggest that Nar1p promotes protection against oxidative stress and define a new role for Nar1p in promoting replicative lifespan.en_US
dc.publisherMech Ageing Deven_US
dc.subjectLifespan; Mitochondrial superoxide dismutase; Nar1en_US
dc.titleNar1 Deficiency Results in Shortened Lifespan and Sensitivity to Paraquat that is Rescued by Increased Expression of Mitochondrial Superoxide Dismutaseen_US
dc.typeArticleen_US


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