Brian Wasko
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Dr. Brian Wasko is an Assistant Professor at University of Houston-Clear Lake. Dr. Wasko's research interests include Biology of Aging, Cellular pH and Metal Homeostasis, Basic Molecular and Cellular Biology.
Recent Submissions
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PMT1 Deficiency Enhances Basal UPR Activity and Extends Replicative Lifespan of Sacchraromyces cerevisiae
(Age (Dordr), 2015)Pmt1p is an important member of the protein O-mannosyltransferase (PMT) family of enzymes, which participates in the endoplasmic reticulum (ER) unfolded protein response (UPR), an important pathway for alleviating ER stress. ... -
Defining Molecular Basis for the Longevity Traits in Natural Yeast Isolates
(NPJ Aging Mechanisms of Disease, 2015)Background: The budding yeast has served as a useful model organism in aging studies, leading to the identification of genetic determinants of longevity, many of which are conserved in higher eukaryotes. However, factors ... -
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging
(Cell Metab, 2015)Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a ... -
Tether Mutations that Restore Function and Suppress Pleiotropic Phenotypes of the C. elegans isp-1(qm150) Rieske Iron-sulfur Protein
(PNAS, 2015)Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood disorders such as Leigh Syndrome, whereas mild disruption can extend ... -
Restoring Membrane Protein Trafficking Rescues the Effects of Aneuploidy on Cellular Aging
(2016)Aneuploidy and aging are correlated; however, a causal link between these two phenomena has remained elusive. Here, we show that yeast disomic for a single native yeast chromosome generally have a decreased replicative ... -
New Functional and Biophysical Insights into the Mitochondrial Rieske Iron-Sulfur Protein from Genetic Suppressor Analysis
(WORM, 2016)Several intragenic mutations suppress the C. elegans isp-1 (qm150) allele of the mitochondrial Rieske iron-sulfur protein (ISP), a catalytic subunit of Complex III of the respiratory chain. These mutations were located ... -
CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes
(PNAS, 2018)Transcriptional regulation plays an important role in the control of gene expression during aging. However, translation efficiency likely plays an equally important role in determining protein abundance, but has been ... -
CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes
(Cell Rep, 2017)Transcriptional regulation plays an important role in the control of gene expression during aging. However, translation efficiency likely plays an equally important role in determining protein abundance, but has been ... -
Transaldolase Inhibition Impairs Mitochondrial Respiration and Induces a Starvation-like Longevity Response in Caenorhabditis Elegans
(PMID, 2017)Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanism exists to cope with disruptions to mitochondrial function that promote cellular health and ... -
Defining the Impact of Mutation Accumulation on Replicative Lifespan in Yeast Using Cancer-associated Mutator Phenotypes
(PNAS, 2019)Mutations accumulate within somatic cells and have been proposed to contribute to aging. It is unclear what level of mutation burden may be required to consistently reduce cellular lifespan. Humans cancers driven by a ... -
Loss of Vacuolar Acidity Results in Iron Sulfur Cluster Defects and Divergent Homeostatic Responses During Aging in Saccharomyces Cerevisiae
(GeroScience, 2020)The loss of vacuolar/lysosomal acidity is an early event during aging that has been linked to mitochondrial dysfunction. However, it is unclear how loss of vacuolar acidity results in age-related dysfunction. Through ...
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