Browsing by Subject "Chemical kinetics. nicotinic, acetylcholine receptor, antiepileptic drugs, noncompetitive inhibition, patch clamp, molecular docking"
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Anticonvulsants Based on the a-substituted Amide Group Pharmacophore Bind to and Inhibit Functions of Neuronal Nicotinic Acetylcholine Receptors (ACS Chemical Neuroscience, 2016)Although the antiepileptic properties of α-substituted lactams, acetamides, and cyclic imides have been known for over 60 years, the mechanism by which they act remains unclear. I report here that these compounds bind to ...