Browsing by Subject "Bisphosphonate, Geranylgeranyl diphosphate, Geranylgeranyl pyrophosphate, Geranylgeranyl diphosphate synthase, Farnesyl diphosphate, Ras Rap1a, Prenylation, Geranylgeranylation, Prodrug, Pivaloyloxymethyl, POM"

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Pivaloyloxtmethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation

Wasko, Brian (Biorg Med Chem, 2008)

Nitrogenous bisphosphonate inhibitors of farnesyl disphosphate synthase have been used clinically for treatment of bone disease. Because many of their effects may be mediated by depletion of geranylgeranyl diphosphate, ...